TABLE 3.

Linear regression associations between postnatal growth (change in standard deviation (SD)-score from birth to three months) and adult levels of fibrinogen?

		Postnatal growth (change in SD-score from birth to 3 months)		Body mass index (kg/m2)		Interactionb
Regression modela	n	β-coefficient (95 % CI)	P-value	β-coefficient (95 % CI)	P-value	β-coefficient (95 % CI)	P-value
(A) Adjusted for age and sex
Early	270	0.11 (0.03, 0.18)	0.004
Later	270			0.04 (0.01, 0.07)	0.004
Combined	270	0.10 (0.03, 0.17)	0.006	0.04 (0.01, 0.07)	0.01
Interactionb	270					0.01 (−0.02, 0.04)	0.42
(B) Adjusted for age, sex and all factors which predicted fibrinogen levelsc
Early	263	0.10 (0.03, 0.16)	0.007
Later	263			0.04 (0.01, 0.06)	0.01
Combined	263	0.09 (0.02, 0.16)	0.008	0.04 (0.01, 0.06)	0.01
Interactionb	263					0.01 (−0.01, 0.04)	0.40

β-coefficient [95% confidence interval (CI)] were calculated using linear regression and represent the increase in fibrinogen for each one unit increase in the explanatory variable.

^aThe early model relates early size (postnatal growth) to later outcome (adult fibrinogen). The later model relates later size (adult body mass index) to later outcome (adult fibrinogen). The combined model is the early model adjusted for later size (adult body mass index).

^bThe interaction model is the combined model including an early size/later size interaction term (postnatal growth × body mass index).

^cFurther adjusted for HDL-cholesterol, white blood cell, granulocyte and monocyte counts, malaria parasitaemia and tobacco use.