Figure 1.

RON modulates TLR4-dependent cytokine production of peritoneal macrophages from FVB or C57Bl6 mice. Peritoneal macrophages from FVB or C57Bl6 were stimulated with Ultrapure LPS (100 ng ml⁻¹) or MSP (100 ng ml⁻¹) separately, or in combination. After overnight culture (20 h), conditioned medium from treatment groups was analyzed for cytokine and chemokine production using a fluorescent-based multiplex assay: (a) TNF-α, (b) IL-12p40, (c) IL-10, (d) CSF-2 and (e) IL-6. Values represent the mean±s.d. of samples from at least two independent experiments analyzed in triplicates.