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. Author manuscript; available in PMC: 2013 Aug 7.

Published in final edited form as: Nat Genet. 2012 Nov 18;44(12):1360–1364. doi: 10.1038/ng.2463

Upper panel: P-values (-log10) of the GWAS (solid circle), replication (triangle) and meta-analysis (asterisk) on the y-axis are plotted against the genomic positions of each SNP on the x-axis on (a) chromosome 20 and on (b) chromosome 7. Horizontal dashed line corresponds to the genome-wide significance threshold of P ≤ 5 × 10⁻⁸. Genes in region are depicted below (not to scale). The LD (r²) between the lead SNP and other SNPs are indicated in different colors. The blue lines indicate the recombination rates in cM per Mb using HapMap controls. Lower panel: LD plots (based on r² value) using genotyped subjects from the GWAS study.

Upper panel: P-values (-log10) of the GWAS (solid circle), replication (triangle) and meta-analysis (asterisk) on the y-axis are plotted against the genomic positions of each SNP on the x-axis on (a) chromosome 20 and on (b) chromosome 7. Horizontal dashed line corresponds to the genome-wide significance threshold of P ≤ 5 × 10⁻⁸. Genes in region are depicted below (not to scale). The LD (r²) between the lead SNP and other SNPs are indicated in different colors. The blue lines indicate the recombination rates in cM per Mb using HapMap controls. Lower panel: LD plots (based on r² value) using genotyped subjects from the GWAS study.