Table 1.
GWAS, replication study and meta-analysis results for most significant SNP on chromosomes 20 and 7
| GWAS | Replication | Meta-analysis | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Chr. | SNP | Allelesa | RAFb | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | P het c |
| 20 | rs1884302 | C/T | 0.3 | 4.58 (2.99–6.97) | 1.1 × 10−14 | 4.30 (3.33–5.56) | 4.4 × 10−31 | 4.38 (3.51–5.45) | 1.1 × 10−39 | 0.81 |
| 7 | rs10262453 | C/A | 0.69 | 0.20 (0.11–0.34) | 1.6 × 10−10 | 0.26 (0.18–0.37) | 3.5 × 10−14 | 0.24 (0.17–0.32) | 5.6 × 10−20 | 0.44 |
a
Minor allele/major allele.
b
Risk allele frequency (RAF) calculated from the replication study controls.
c
P value for heterogeneity between the discovery and replication cohorts. Underlined bases are overtransmitted alleles. Chr., chromosome.