Table 3.
PK Parameters | F-DTX (IV) | F-DTX (oral) | Ch20-GSH NPs (oral) |
---|---|---|---|
T max (h) | 0.5 | 2 | 5 |
C max (ng/mL) | 14,744 ± 2,354 | 456 ± 54.1 | 341 ± 47.5 |
AUC0–∞ (h·ng/mL) | 65,245 ± 4,545 | 4,243 ± 207 | 44,998 ± 3,534 |
T 1/2 (h) | 2.7 ± 0.6 | 11.7 ± 1.45 | 102.5 ± 12.6 |
MRT (h) | 3.2 ± 0.3 | 15.7 ± 1.6 | 144.0 ± 10.7 |
Absolute bioavailability | — | 6.5% | — |
Relative bioavailability | — | — | 68.9% |