Table 2.
Methods for structure-based B-cell epitopes prediction.
| Method | Online service (program) | Brief notes (features used in prediction method) |
|---|---|---|
| CEP [30, 36] | Available upon request | First Web-based conformational B-cell epitopes prediction software, based on the surface accessible |
| DiscoTope [37] | http://www.cbs.dtu.dk/services/DiscoTope/ | Amino acid statistics, spatial context, and surface accessibility |
| Rapbergera [38] | Not stated | Based on antibody information |
| ElliPro [40] | http://tools.immuneepitope.org/tools/ElliPro/iedb_input | Prominent index |
| PEPITO/BEPro [41] | http://pepito.proteomics.ics.uci.edu/ | Half sphere exposure values |
| PEPOP [42] | Available upon request | Accessible and sequence contiguous amino acids segments |
| SEPPA [45] | http://lifecenter.sgst.cn/seppa/index.php | Unit patch of residue triangle |
| Epitopia [46] | http://epitopia.tau.ac.il/ | Based on Naïve Bayes classifier with physicochemical and structural geometrical properties |
| EPCES [47] | http://sysbio.unl.edu/services/EPCES/ | Consensus score by six functions |
| Shinji Sogaa [49] | Not stated | Antibody-specific epitope propensity index |
| EPSVR & EPMeta [51] | http://sysbio.unl.edu/services/ | Based on SVR and meta-analysis |
| Zhanga [52] | http://code.google.com/p/my-project-bpredictor/downloads/list | Based on random forests with a distance-based feature |
aThe name of the first author is used if the method has no name.