Table 2B.
Characteristics of patients who are died after transplantation
| Age at diagnosis |
Age at transplant |
Year of transplant |
Donor source |
Conditioning regimen |
GVHD | Time to last |
Cause of death |
|---|---|---|---|---|---|---|---|
| 4.1 years | 8.0 years | 1981 | HLA- matched sibling |
TBI 450 cGy+ cyclophosphamide |
Chronic | 71.1 months |
GVHD |
| 17.5 years | 26.0 years | 1984 | Mismatched relative |
TBI 500 cGy + cyclophosphamide |
None | 2.6 months |
Graft failure |
| 3.8 years | 5.0 years | 1990 | HLA- matched sibling |
Cyclophosphamide | Acute & Chronic |
111.3 months |
Pulmonary failure |
| 1.7 years | 2.1 years | 1992 | Mismatched unrelated donor |
Busulfan + cyclophosphamide |
None | 1.3 months |
Graft failure |
| 8.8 years | 16.3 years | 1993 | HLA- matched sibling |
Cyclophosphamide | None | 144.0 months |
Pulmonary failure |
| 4.7 years | 10.0 years | 1993 | Mismatched relative |
Busulfan + fuldarabine |
Acute & Chronic |
16.8 months |
Infection |
| 4.14 years | 7.6 years | 1994 | HLA- matched sibling |
TBI + cyclophosphamide |
Acute & Chronic |
3.8 months |
ARDS |
| 9.6 years | 13.6 years | 1994 | HLA- matched sibling |
Busulfan + fludarabine |
Acute | 27.5 months |
Pulmonary failure |
| 5.0 years | 8.0 years | 1996 | Mismatched unrelated donor§ |
Busulfan + cyclophosphamide |
Acute | 2.9 months |
Graft failure |
| 11.8 years | 25.8 years | 1998 | Mismatched unrelated donor |
TBI 400 cGy+ cyclophosphamide |
None | 3.3 months |
Graft failure |
| 5.1 years | 8.0 years | 1998 | HLA- matched sibling |
Cyclophosphamide | None | 120.0 months |
Pulmonary failure |
| 5.5 years | 7.5 years | 2000 | HLA- matched sibling |
Cyclophosphamide + fludarabine |
None | 16.1 months |
Graft failure |
| 4.5 years | 13.0 years | 2001 | HLA- matched sibling* |
Busulfan + fludarabine |
Acute | 70.5 months | Not reported |
| 10.0 years | 13.2 years | 2003 | Mismatched unrelated donor* |
Cyclophosphamide + fludarabine |
None | 2.0 months |
Graft failure |
| 32.1 years | 33.0 years | 2003 | Mismatched unrelated donor§ |
Melphalan + fludarabine |
None | 1.6 months |
Hemorrhage |
| at birth | 17.8 years | 2004 | Matched unrelated donor* |
TBI 200 cGy + fludarabine |
Acute | 87.5 months |
Pulmonary failure |
| 21.2 years | 22.0 years | 2005 | Mismatched unrelated donor |
Melphalan + fludarabine |
Chronic | 16.2 months |
Graft failure |
| 23.0 years | 24.0 years | 2005 | Mismatched unrelated donor§ |
TBI 200 cGy + cyclophosphamide |
None | 2.1 months |
Graft failure |
| 11.9 years | 29.4 years | 2008 | Matched unrelated donor |
Cyclophosphamide | None | 1.8 months |
Encephalopathy |
| 22.0 years | 22.9 years | 2009 | Matched unrelated donor |
TBI 200 cGy | None | 0.6 months |
Infection |
*
peripheral blood progenitor cells
§
umbilical cord blood; others received bone marrow
+
indicate additional drugs.
Abbreviations: TBI, total body irradiation; ARDS, acute respiratory distress syndrome