Table 4. Association of SNPs with plasma adiponectin levels in the IRASFS African American cohort.
SNPs are divided into two categories based on frequency, rare/low frequency (LF) variants and common variants. For each SNP the position (hg18), location relative to the ADIPOQ gene, and corresponding amino acid change (if applicable) is listed. The alleles for each SNP (major/minor) are listed with the corresponding minor allele frequency (MAF). Genotypic means ± standard deviation are listed by genotype where 1 and 2 are the major and minor alleles, respectively. The unadjusted association p-value is listed with the beta value indicating direction of effect.
| Amino Acid Change | Genotypic mean +/− SD |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Position | Location | Alleles1 | MAF2 | 1 / 1 | 1 / 2 | 2 / 2 | P-value3 | beta | ||
| rare/LF variants | rs17300539 | 188042154 | 5′ | G / A | 0.028 | 8.98 ± 5.25 | 11.16 ± 5.21 | - | 0.0018 | 0.32 | |
| rs822391 | 188046497 | intron 1 | T / C | 0.031 | 8.97 ± 5.11 | 9.49 ± 4.34 | 8.13 ± 2.94 | 0.67 | −0.031 | ||
| rs822394 | 188049422 | intron 1 | C / A | 0.029 | 8.93 ± 5.06 | 9.92 ± 4.62 | 5.87 ± 3.14 | 0.88 | −0.010 | ||
| rs17366568 | 188053147 | intron 1 | G / A | 0.037 | 9.11 ± 5.34 | 8.36 ± 3.77 | 13.13 | 0.56 | 0.052 | ||
| rs2241766 | 188053586 | exon 2 | G15G | T / G | 0.031 | 8.97 ± 5.04 | 9.29 ± 5.01 | - | 0.62 | 0.043 | |
| C113T | 188053654 | exon 2 | G38D | G / A | 0.019 | 9.04 ± 5.28 | 9.81 ± 4.33 | - | 0.76 | −0.041 | |
| C163T | 188053704 | exon 2 | R55C | C / T | 0.010 | 9.06 ± 5.01 | 1.20 ± 0.37 | - | 0.00030 | −1.00 | |
| rs2241767 | 188053890 | intron 2 | A / G | 0.028 | 9.06 ± 5.27 | 9.52 ± 5.26 | - | 0.31 | 0.087 | ||
| rs3774262 | 188054508 | intron 2 | G / A | 0.028 | 9.05 ± 5.26 | 9.52 ± 5.26 | - | 0.30 | 0.088 | ||
| rs17366743 | 188054783 | exon 3 | Y111H | T / C | 0.010 | 9.02 ± 5.04 | 7.28 ± 4.04 | - | 0.35 | −0.20 | |
| T491C | 188054943 | exon 3 | I164T | T / C | 0 | 9.07 ± 5.27 | 10.45 | - | 1.00 | 0.00 | |
| rs1865762 | 188062094 | 3′ | A / G | 0.010 | 8.95 ± 5.00 | 11.50 ± 5.69 | - | 0.17 | 0.19 | ||
| rs17373414 | 188068221 | 3′ | C / T | 0.020 | 8.96 ± 4.99 | 11.05 ± 6.10 | - | 0.47 | 0.10 | ||
| common variants | rs7648121 | 68183280 | 5′ | C / T | 0.061 | 8.63 ± 4.85 | 10.68 ± 5.53 | - | 0.0052 | 0.15 | |
| rs6810075 | 188031259 | 5′ | T / C | 0.43 | 8.78 ± 4.83 | 9.19 ± 5.36 | 9.72 ± 62021 | 0.72 | 0.011 | ||
| rs10937273 | 188032389 | 5′ | G / A | 0.13 | 8.66 ± 4.94 | 10.07 ± 5.19 | 6.74 ± 3.54 | 0.15 | 0.063 | ||
| rs1648707 | 188034405 | 5′ | A / C | 0.39 | 9.25 ± 4.73 | 9.19 ± 5.09 | 8.48 ± 5.10 | 0.017 | −0.072 | ||
| rs864265 | 188036986 | 5′ | G /T | 0.065 | 9.09 ± 5.39 | 9.00 ± 4.91 | 10.31 ± 2.02 | 0.89 | −0.0060 | ||
| rs822387 | 188038731 | 5′ | T / C | 0.33 | 9.43 ± 5.10 | 8.88 ± 4.96 | 7.68 ± 4.95 | 0.23 | −0.042 | ||
| rs16861194 | 188042119 | 5′ | A / G | 0.32 | 8.98 ± 5.13 | 8.93 ± 4.93 | 9.51 ± 4.83 | 0.79 | 0.010 | ||
| rs266729 | 188042168 | 5′ | C / G | 0.11 | 8.92 ± 4.83 | 9.38 ± 5.73 | 14.01 | 0.44 | −0.040 | ||
| rs710445 | 188044212 | intron 1 | A / G | 0.44 | 8.63 ± 4.74 | 9.30 ± 5.44 | 9.11 ± 4.50 | 0.86 | 0.0054 | ||
| rs16861205 | 188044328 | intron 1 | G / A | 0.26 | 8.86 ± 5.16 | 9.36 ± 4.85 | 8.88 ± 5.04 | 0.76 | 0.011 | ||
| rs16861209 | 188045808 | intron 1 | C / A | 0.14 | 8.90 ± 5.20 | 9.26 ± 4.51 | 9.16 ± 5.61 | 0.034 | 0.086 | ||
| rs822396 | 188049571 | intron 1 | A / G | 0.19 | 9.34 ± 5.18 | 8.75 ± 5.44 | 7.44 ± 5.00 | 0.060 | −0.071 | ||
| rs12495941 | 188050874 | intron 1 | G / T | 0.39 | 7.51 ± 4.43 | 9.57 ± 5.61 | 9.08 ± 4.94 | 0.77 | −0.0091 | ||
| rs9877202 | 188052301 | intron 1 | A / G | 0.13 | 9.26 ± 5.19 | 8.06 ± 4.31 | 6.94 ± 3.94 | 0.21 | −0.059 | ||
| rs2036373 | 188052885 | intron 1 | T / G | 0.083 | 8.92 ± 5.07 | 10.43 ± 6.46 | 6.39 ± 4.09 | 0.88 | −0.0092 | ||
| rs3774261 | 188054253 | intron 2 | G / A | 0.40 | 8.44 ± 4.68 | 9.22 ± 5.56 | 9.20 ± 5.10 | 0.16 | 0.041 | ||
| rs6444174 | 188055883 | 3′ UTR | T / C | 0.21 | 9.15 ± 5.12 | 8.73 ± 4.88 | 8.57 ± 4.30 | 0.16 | −0.056 | ||
| rs6773957 | 188056399 | 3′ UTR | G / A | 0.40 | 8.44 ± 4.68 | 9.22 ± 5.56 | 9.20 ± 5.10 | 0.16 | 0.041 | ||
| rs2082940 | 188056858 | 3′ UTR | C / T | 0.23 | 9.31 ± 5.47 | 8.52 ± 4.79 | 9.39 ± 4.91 | 0.20 | −0.047 | ||
| rs9842733 | 188058176 | 3′ UTR | A / T | 0.13 | 9.11 ± 5.03 | 8.73 ± 5.13 | 6.11 ± 2.65 | 0.78 | 0.015 | ||
| rs1403697 | 188059387 | 3′ | A / G | 0.18 | 9.04 ± 5.07 | 8.81 ± 4.82 | 9.77 ± 5.97 | 0.90 | 0.0055 | ||
| rs7639352 | 188061168 | 3′ | C / T | 0.33 | 8.62 ± 4.67 | 9.18 ± 5.76 | 10.20 ± 4.94 | 0.026 | 0.072 | ||
| rs7641507 | 188061267 | 3′ | C / T | 0.094 | 9.03 ± 5.09 | 9.11 ± 4.77 | 7.89 ± 0.43 | 0.61 | −0.030 | ||
| rs6444175 | 188062438 | 3′ | G / A | 0.33 | 8.74 ± 4.64 | 8.97 ± 5.33 | 10.21 ± 4.98 | 0.024 | 0.076 | ||
| rs1403696 | 188062560 | 3′ | C / T | 0.26 | 9.19 ± 5.48 | 8.71 ± 4.67 | 9.58 ± 5.52 | 0.39 | −0.032 | ||
| rs13085499 | 188063534 | 3′ | G / A | 0.34 | 9.41 ± 5.10 | 9.18 ± 5.56 | 8.06 ± 4.64 | 0.072 | −0.054 | ||
| rs7628649 | 188068075 | 3′ | C / T | 0.33 | 9.17 ± 5.64 | 8.87 ± 4.70 | 9.60 ± 5.46 | 0.48 | −0.023 | ||
Alleles listed as major allele / minor allele
Assuming the Bonferroni correction for 40 SNPs, we have power of 0.29, 0.53, 0.72 and 0.86 in African Americans for variants explaining 0.02, 0.03, 0.04 and 0.05 of the variation in adiponectin.
A strict Bonferroni correction for 40 tests (SNPs) would result in a significant threshold P<0.0013.