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. 2013 Aug 6;105(3):794–806. doi: 10.1016/j.bpj.2013.06.038

Figure 6.

Figure 6

Response to LTP and LTD protocols. In each figure, the system begins with all subunits in the Duu state, and the first stimulation protocol is applied at t = 0. After the first stimulation protocol, the system is allowed to relax to its steady state at basal calcium. We then apply a second stimulation protocol (identical to the first), after which the system is again allowed to relax to steady state. The axes are cut to highlight various sections of interest. (A) LTD protocol. In this case, CaMKII activity oscillates in time with the stimulation and there is no significant accumulation of active subunits. The first and second stimuli produce identical responses. (B) LTD protocol. In this case, CaMKII activity slowly accumulates with each pulse, and does not plateau during the time course of the stimulation. The response to the second stimulus is significantly attenuated, because a significant fraction of subunits are doubly inhibited in the steady state. (C) LTP protocol. CaMKII is rapidly activated and then plateaus. Activity decays in a biexponential manner with a very fast and a very slow time constant, as discussed in the text. The response to the second stimulus is attenuated, as in B. See the text for more details.