Figure 7.
Characterization of response to LTP protocols. The decay of CaMKII activity after LTP stimulation was fit to a double exponential, and the fitted parameters are plotted as functions of PP1. The response to the first stimulation is shown in blue and the response to the second stimulation in red. (a) a1 gives the concentration of active subunits that are CaM-bound but not phosphorylated, i.e., the nonautonomous portion of CaMKII activity. (b) τ1 is the fast decay time, which is controlled by the dissociation of CaM from nonautonomous subunits. (c) a2 gives the concentration of autonomous CaMKII generated in response to the stimulation protocol. (d) τ2 characterizes the slow decay time for the loss of autonomous activity due to dephosphorylation.