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Cartoon showing differences in the interaction of LLP2 with T-cell and HIV membranes. (a) WT LLP2 binds to the outer headgroup region and thins the T-cell membrane. (b) MX2 LLP2 binds more deeply into the hydrocarbon interior and thins the T-cell membrane to a greater extent. (c) WT and MX2 LLP2 only weakly bind to the HIV virion membrane.
