Figure 8.

SS-31 prevents tubular cell apoptosis caused by 30 minutes of ischemia. Representative TUNEL staining in the outer medulla 24 hours after ischemia injury from (A) sham, (B) saline-treated, and (C) SS-31–treated kidneys. Original magnification, ×200. TUNEL-positive cells are indicated by arrows. Asterisks show necrotic cells. Apoptotic cells were seen in both proximal (P) and distal (D) tubules. Necrotic cells were seen more often in proximal tubules. SS-31 reduced apoptotic cells in both proximal and distal tubules. Data are represented as mean ± SEM. ***P<0.001.