Figure 6.

MSC-like cells participating in JG cell recruitment represent resident progenitor cells of the adult kidney. Bone marrow transplantation was performed with GFP-transgenic mice as donors and wild-type mice as recipients, followed by low-salt/captopril treatment or normal diet for 10 days. (A) Representative immunofluorescence (original magnification, 10×) of five independent experiments staining for renin (red) in kidneys from control and treated animals. G, glomerulus. (B) FACS analysis of CD44 (phycoerythrin–labeled) and GFP⁺ or GFP⁻ cells in kidney of mice with bone marrow transplantation after low-salt/captopril treatment or normal chow diet. (C) Renin mRNA expression determined by real-time PCR in GFP⁺ cells from kidneys of mice with bone marrow transplantation under low-salt/captopril treatment or normal diet as control. Data presented as the mean + SEM of five independent experiments; *P<0.05 treated versus control.