Table 2.

Metabolites significantly associated with incident CKD in FHS

Metabolite	Geometric Mean Ratio in FHS (95% CI)	P Value
Xanthosine	1.19 (1.13 to 1.27)	5.2 × 10−9
Citrulline	1.13 (1.08 to 1.18)	2.0 × 10−8
Isocitrate	1.14 (1.09 to 1.20)	9.1 × 10−8
Aconitate	1.13 (1.08 to 1.19)	9.4 × 10−8
Choline	1.08 (1.05 to 1.12)	3.7 × 10−7
Kynurenine	1.13 (1.08 to 1.19)	4.1 × 10−7
β-aminoisobutyric acid	1.22 (1.13 to 1.34)	1.1 × 10−6
Kynurenic acid	1.25 (1.14 to 1.38)	1.4 × 10−6
Trimethylamine-N-oxide	1.33 (1.18 to 1.49)	1.6 × 10−6
Adenosine	1.50 (1.27 to 1.77)	2.0 × 10−6
5-hydroxyindoleacetic acid	0.73 (0.64 to 0.83)	3.3 × 10−6
Quinolinic acid	1.19 (1.10 to 1.28)	5.1 × 10−6
LPC18:2	0.90 (0.85 to 0.94)	1.9 × 10−5
Sucrose	1.39 (1.19 to 1.63)	4.7 × 10−5
LPC18:1	0.91 (0.86 to 0.95)	1.0 × 10−4
Inositol	1.19 (1.09 to 1.30)	1.2 × 10−4

LPC, lysophosphatidylcholine.