Table 6.

Relationship of baseline metabolite levels and incident CKD

Metabolite	Odds Ratio per SD (95% CI)	P Value
Kynurenic acid	1.53 (1.25 to 1.88)	<0.0001
Kynurenine	1.49 (1.22 to 1.83)	0.0001
Citrulline	1.48 (1.19 to 1.83)	0.0004
Choline	1.46 (1.17 to 1.82)	0.0007
Xanthosine	1.46 (1.21 to 1.76)	<0.0001
β-aminoisobutyric acid	1.41 (1.15 to 1.72)	0.0008
Aconitate	1.32 (1.07 to 1.62)	0.0092
Isocitrate	1.28 (1.05 to 1.58)	0.017
5-hydroxyindoleacetic acid	0.62 (0.51 to 0.76)	<0.0001

Odds ratios for CKD obtained from logistic regressions. All models adjusted for eGFR, age, sex, diabetes, hypertension, and proteinuria at baseline.