Figure 2.

KO mice exhibited a mildly diabetic phenotype with no signs of impaired insulin sensitivity or overt pancreatic function. (A) Fasting plasma glucose levels in tail blood of 8-hour-fasted KO mice relative to WT littermates. (B) Plasma glucose clearance was measured in response to intraperitoneal glucose (5 ml of 20% dextrose/kg body weight). (C) Plasma insulin levels before and 20 minutes after intraperitoneal glucose injection (n=8/genotype). (D) Measurement of insulin sensitivity in mice using hyperinsulinemic-euglycemic clamp. *P<0.05 between the two genotypes by unpaired t test.