Table 1.
PLA2R1 and HLA-DQA1 polymorphisms in patients with IMN and healthy controls in a Chinese population
| Variant | Gene | Position | Allele | Controls (n=1020) | IMN Patients (n=1112) | OR (95% CI)a | P Value | Adjusted P Valueb |
| rs35771982 | PLA2R1 | Exon 5 | C | 615 (30.1) | 344 (15.5) | 2.36 | 1.90×10−30 | 1.14×10−29 |
| G | 1425 (69.9) | 1880 (74.5) | (2.03 to 2.74) | |||||
| rs3749117 | PLA2R1 | Exon 5 | C | 611 (30.0) | 346 (15.6) | 2.32 | 2.23×10−29 | 1.34×10−28 |
| T | 1429 (70.0) | 1878 (84.4) | (2.00 to 2.69) | |||||
| rs4664308 | PLA2R1 | Intron | A | 1427 (70.0) | 1880 (84.5) | 2.35 | 4.17×10−30 | 2.50×10−29 |
| G | 613 (30.0) | 344 (15.5) | (2.02 to 2.73) | |||||
| rs2187668 | HLA-DQA1 | Intron | A | 110 (5.4) | 270 (12.1) | 2.42 | 1.11×10−14 | 6.66×10−14 |
| G | 1930 (94.6) | 1954 (87.8) | (1.93 to 3.05) | |||||
| rs11244 | HLA-DOB | 3′ untranslated region variant | C | 1506 (73.9) | 1641 (73.8) | 1.001 | 0.98 | — |
| T | 534 (26.1) | 583 (26.2) | (0.87 to 1.15) | |||||
| rs2301271 | HLA-DQB2 | Intron | C | 1719 (84.3) | 1851 (83.2) | 1.08 | 0.36 | — |
| T | 321(15.7) | 373 (16.8) | (0.92 to 1.27) |
a
OR modeled for minor allele.
b
Bonferroni correction was used when the adjusted P value was reported.