Effect of sorafenib on hemodynamic measurements. (a, b) PA and RV systolic pressures, respectively, obtained in Dahl SS rodents at 3.5-week exposure to normoxia (n = 7), hypoxia/SU5416 (H-SU5416, n = 5), or hypoxia/SU5416/sorafenib treatments (H-SU-Sor, n = 5). (c) RV hypertrophy (RVH) measurements across all of the tested conditions represented by the ratio of RV mass divided by the sum of the mass of left ventricle (LV) plus septum (LV + septum). *p < 0.01, **p < 0.001