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Glutathione synthesis pathway. Glutathione is synthesized from L-glutamate and L-cysteine in a 2-step reaction catalyzed in an ATP dependent manner by γ-glutamylcysteine ligase (GCL) (also referred to as γ-glutamylcysteine synthetase) and the addition of glycine by glutathione synthase. Glutathione can be recycled to its constitutive amino acids by γ-glutamyl-n-transferase and dipeptidase.
