Table 3.
Frequency of interaction between TM helix polar or charged side chains and phospholipid headgroups observed in the last 10 ns of restrained MDa
S1/M1 | S1/M2 | S2/M1 | S2/M2 | |
---|---|---|---|---|
Tyr-25 | 0.91 | 0.92 | 0.89 | 0.93 |
Tyr-40 | 0.81 | 0.73 | 0.61 | 0.95 |
Ser-41 | 0.95 | 0.90 | 0.62 | 0.82 |
Arg-44 | 1.00 | 1.00 | 1.00 | 0.96 |
Lys-45 | 0.77 | 0.96 | 0.77 | 0.93 |
The interaction occurs when any heavy atom of a particular residue’s side chain is within 4 Å of a lipid headgroup atom.