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Pol III and TLS replisomes. Conversion of the coupled Pol III replisome to an uncoupled alternative TLS replisome. A) The coupled trimeric Pol III holoenzyme-DnaB replisome. B) Take-over of beta clamps by a TLS Pol displaces Pol III form the fork, resulting in a TLS Pol-replisome in which TLS Pols act distributively on beta clamps.
