TABLE 4.

TEG Parameters on Blood From Healthy Volunteers at Baseline and After the Addition of Apheresis Platelets

	Baseline (n = 10)	Platelets (n = 10)	p
R, mean (SEM), min	10.22 ± 0.52	7.12 ± 0.25	<0.0001
K, mean (SEM), min	2.99 ± 0.14	1.66 ± 0.08	<0.0001
Angle, mean (SEM), degrees	51.43 ± 1.48	66.63 ± 1.05	<0.0001
MA, mean (SEM), mm	58.90 ± 1.10	67.40 ± 0.62	<0.0001
G, mean (SEM), dynes/cm2	7.19 ± 0.35	10.34 ± 0.29	<0.0001
TG, mean (SEM), mm/min	713.86 ± 12.19	814.42 ± 7.97	<0.0001
Platelet count, mean (SEM), 1,000/µL	96.44 ± 9.82	324.22 ± 35.82	<0.0001
Fibrinogen, mean (SEM), mg/dL	274.03 ± 15.82	427.95 ± 16.58	<0.0001
% Fib, mean (SEM)	25.79% ± 1.55%	34.90% ± 1.06%	0.0006
% Plt, mean (SEM)	74.21% ± 1.55%	65.10% ± 1.06%	0.0006

All TEG parameters significantly changed to promote a hypercoagulable state. Interestingly, thrombin generation (TG), fibrinogen, and the percent fibrinogen contribution to clot strength (% Fib) significantly increased, while the percent platelet contribution to clot strength (% Plt) decreased.

All p values were from a paired t test for continuous variables.

G, clot strength; K, kinetic time; MA, maximum amplitude; R, reaction time; TG, thrombus generation.