Table 1.

Differential Diagnosis of Malignant and Benign Solid Pancreatic Lesions

Malignant tumors

Primary pancreatic ductal adenocarcinoma (>85%)

Secondary metastatic tumors

Lung

Breast

Renal

Prostate

Melanoma

Gastrointestinal tract carcinoma (eg, esophageal, gastric, ampullary, and colorectal)

Osteosarcoma

Neuroendocrine tumors

Lymphoma

Solid pseudopapillary tumors

Pancreatic acinar cell carcinoma

Malignant cystic lesions with solid components (mucinous cystadenoma or intraductal papillary mucinous neoplasm)

Benign tumors and pseudotumors

Focal pancreatitis and chronic pancreatitis

Autoimmune pancreatitis

Microcystic serous cystadenoma

Other masquerading lesions, such as splenule