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. 2013 May 10;22(17):3508–3523. doi: 10.1093/hmg/ddt206

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Published by Oxford University Press 2013. This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 3. — HPβCD treatment reverses lipid storage and alters gene expression in NPC1ASO liver. (A) HPβCD treatment reduced the significantly elevated unesterified cholesterol in NPC1ASO liver from 13.6 ± 0.8 to 6.8 ± 0.5 mg/g. (B) The significantly elevated total cholesterol in NPC1ASO liver was decreased from 14.0 ± 0.9 to 7.8 ± 0.5 mg/g after HPβCD treatment. (C) The significantly elevated mRNA expression of Srebp2 and Itgax in NPC1ASO liver was reduced by HPβCD treatment, consistent with reductions in cholesterol synthesis and inflammation. The expression levels of mRNA are the relative fold change over untreated CTLASO. Data analyzed by two-way ANOVA with post-tests; column lettering (a, b, c) indicates significance (P < 0.05), as described in Figure 1.