Table 3.
Half-maximal dose concentration (pEC50) of the offspring aortic rings towards various drugs.
| P/P | P/C | C/C | C/P | Pre | Post | Pre × Post | |
|---|---|---|---|---|---|---|---|
| Phenylephrine | 8.2 ± 0.1a | 7.8 ± 0.2ab | 7.6 ± 0.2ab | 7.3 ± 0.1b | P = 0.009 | NS | NS |
| U46619 | 7.4 ± 0.1 | 7.4 ± 0.2 | 7.7 ± 0.1 | 7.3 ± 0.1 | NS | NS | NS |
| Acetylcholine | 7.4 ± 0.2 | 7.3 ± 0.1 | 7.1 ± 0.1 | 6.9 ± 0.1 | P = 0.012 | NS | NS |
| Sodium nitroprusside | 8.1 ± 0.1 | 8.1 ± 0.1 | 7.7 ± 0.1 | 7.9 ± 0.1 | P = 0.014 | NS | NS |
Notes: Data represents means ± SEM (n = 6–8, specified in section 2.6). Two way ANOVA followed by Tukey’s HSD post Hoc analysis was performed to assess the effects of pre-weaning diet, post-weaning diet and of their interaction (Pre × Post) on various parameters. Different superscripts represent significant differences of P < 0.05.
Abbreviations: P/P = offspring fed n-6 PUFA-rich diet both during pre- and post-weaning time periods; P/C, offspring fed n-6 PUFA-rich diet during pre-weaning alone; C/C, offspring fed control diet both during pre- and post-weaning time periods; C/P, offspring fed n-6 PUFA-rich diet during post-weaning alone; Pre, pre-weaning; Post, post-weaning; NS, non-significant.