Table 1.
Characteristics of the participants of the AGENDA trial at entry.
| Escitalopram (n = 41) | Placebo (n = 39) | All (n = 80) | |
|---|---|---|---|
| Age – years, mean ± SD | 32 ± 11 | 31 ± 11 | 32 ± 10 |
| Women – N (%) | 15 (37) | 14 (36) | 29 (36) |
| Proband was/– N (%) | |||
| Sibling | 18 (44) | 15 (39) | 33 (41) |
| Parent | 23 (56) | 24 (62) | 47 (59) |
| White – (%) | 100 | 100 | 100 |
| Education – mean ± SD | |||
| Years of school | 11 ± 1 | 11 ± 1 | 11 ± 1 |
| Further education score | 3 ± 2 | 3 ± 2 | 3 ± 2 |
| Employment status – N (%) | |||
| Employed | 30 (73) | 26 (67) | 56 (70) |
| Student | 11 (27) | 11 (28) | 22 (28) |
| Unemployed | 0 (0) | 2 (5) | 2 (3) |
| First-degree relatives of patient with a history of major depressive disorder – median (quartiles)* | 1 (1;2) | 1 (1;2) | 1 (1;2) |
| Second-degree relatives with a history of major depressive disorder – median (quartiles) | 0 (0;1) | 0 (0;1) | 0 (0;1) |
| 17-item Hamilton Depression Scale Score, – median (quartiles) (range) | 1 (0;3) | 1 (0;3) | 1 (0;3) |
| (0–7) | (0–7) | (0–7) | |
| 14-item Hamilton Anxiety Scale Score, – median (quartiles) (range) | 1 (0;2) | 1 (0;2) | 1 (0;2) |
| (0–9) | (0–6) | (0–9) | |
| Beck Depression Inventory, 21-item, depression – median (quartiles) | 2 (0;4) | 2 (0;3) | 2 (0;5) |
| Beck Depression Inventory, 14-item, anxiety – median (quartiles) | 1 (0;4) | 2 (0;3) | 1 (0;3) |
| Daily medicine – N (%)** | 2 (5) | 4 (10) | 6 (8) |
| Danish Adult Reading Test 45 words mean ± SD*** (range) | 24.4 ± 8.4 | 25.1 ± 7.4 | 24.4 ± 7.8 |
| (6–40) | (8–38) | (6–40) | |
Notes: Two participants smoked cannabis more than 2 months prior to the investigation. Three were previously abusing alcohol. One participant had generalized anxiety.
*
Quartiles reported, are the 25 and 75 quartiles.
**
No benzodiazepines or antihistamines.
***
Missing data for one participant with dyslexia.