Table 2.

Proposed factors determining sensitivity to psychosis in cannabis users.^*

Sensitivity to psychosis as determined by:	Possible sensitivity factors	Study group
Predisposition to psychosis	Family history of psychotic illness	McGuire et al. [1995]
	Presence of subclinical psychotic symptoms	Henquet et al. [2004]
	Ultra high risk groups	Peters et al. [2009]
Personality	Schizotypal personality disorder	Barkus et al. [2006]; Stirling et al. [2008]; Anglin et al. [2012]
Psychosis susceptibility genes	COMT	Caspi et al. [2005]
	AKT1	van Winkel et al. [2011]
	AKT1 and DAT1	Bhattacharyya et al. [2012]

^*Please note that except for the schizotypal personality disorder, the other studies need to be replicated.

AKT1, serine-threonine protein kinase; COMT, catechol-O-methyltransferase; DAT1, dopamine transporter gene.