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Constitutively trimerized human HSF1 alleles have mutations in leucine zippers. (A) Schematic showing the location of mutations identified in this study that promote human HSF1-dependent yeast growth. (B) Mutations that promote human HSF1 dependent yeast growth mutate key residues in leucine zipper domains. For reference, black dots are placed at five amino acid intervals. (C) Mutations that promote human HSF1 dependent yeast growth occur in highly conserved amino acid residues.
