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The L189P HSF1 mutant exhibits genomic locus dependent deficiencies in DNA binding. hsf1−/− MEFs were transfected with a plasmid expressing wild-type HSF1 or the HSF1 mutants identified in this screen and analyzed for HSF1 DNA binding by chromatin immunoprecipitation at the Hsp70, Hsp25 and IL-6 promoters under normal growth conditions (37°) or 1 hr heat shock at 42°.
