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. 2013 Aug 7;8(8):e70437. doi: 10.1371/journal.pone.0070437

Figure 3. Role of PDGF receptor in MS-induced Akt phosphorylation in VSMC.

Figure 3

(A) Representative Western blots for the phosphorylated Akt (p-Akt) and total Akt (Akt) in cells stimulated by 10% MS at the indicated time (n = 5). (B–E) Representative Western blots for p-Akt and Akt in cells stimulated by 10% MS for 4 hrs in the absence (Veh) or presence of inhibitors for various growth factor receptors, including AG1295 (a PDGF receptor inhibitor), AG1478 (an EGF receptor inhibitor), AG1024 (an IGF receptor inhibitor), and PD173074 (a FGF receptor inhibitor). Right panels represent quantitative data for the corresponding blots in the left panels, and data are presented as means ± SEM (n = 6). **p<0.01 vs. control (Con). ##p<0.01 vs. vehicle (Veh). (F–I) Cell viability in VSMC treated with various inhibitors are represented as % of control, and data are presented as the means ± SEM (n = 4).