Figure 7. The individual roles of PDGFR isoforms in MS-induced MMP-2 production in VSMC.

Cells were transfected with the indicated doses of PDGFR-α siRNA or PDGFR-β siRNA, and then stimulated with 5 ng/ml PDGF-BB (A and B) as well as by 10% MS (C and D) for 12 hrs. MMP-2 activity and production were determined using gelatin zymography and Western blot, respectively. Quantitative data for the corresponding blots are presented as means ± SEM (n = 6). **p<0.01 vs. corresponding control (Con). #p<0.05, ##p<0.01 vs. corresponding vehicle (Veh).