Table 3.
Hazard ratios (HRs) of 33-month mortality according to the tertiles soluble endotoxin receptor CD14 of in 310 maintenance hemodialysis patients
| Unadjusted | Case-mix1 adjusted | Case-mix + MICS2 adjusted | Case-mix + MICS + inflammation adjusted (Full model)3 | ||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| CD14 Tertiles | death | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P |
| Tertile 1: <6 (n=103) | (n=14) | 1.0 (Reference) | 1.0 (Reference) | 1.00 (Reference) | 1.00 (Reference) | ||||
| Tertile 2: 6 to 7.84 (n=104) | (n=23) | 1.52 (0.78–2.98) | 0.2 | 1.46 (0.74–2.89) | 0.2 | 1.37 (0.68–2.74) | 0.3 | 1.26 (0.62–2.53) | 0.5 |
| Tertile 3: >7.8 (n=103) | (n=34) | 2.59 (1.39–4.83) | 0.003 | 2.49 (1.33–4.68) | 0.004 | 2.09 (1.09–4.00) | 0.02 | 1.94 (1.01–3.75) | 0.04 |
1
Case-mix variables include age, sex, race/ethnicity, diabetes, Log vintage
2
MICS variables include albumin, creatinine, hemoglobin, total iron binding capacity, normalized protein catabolic rate (nPCR), lymphocyte percent, and body mass index
3
Full model consist of case-mix and MICS variables, and logarithm of three inflammatory markers: C-reactive protein, Interleukin-6, Tumor necrosis factor-α