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. 2013 Aug 7;8(8):e70925. doi: 10.1371/journal.pone.0070925

Figure 2. Specific cathepsin K knockdown significantly reduces HSC-3 cell invasion in the myoma organotypic invasion model.

Figure 2

The knockdown of cathepsin K mRNA has significantly decreased the invasion of HSC-3 shRNA CTSK cells in the myoma organotypic model when compared with HSC-3 shRNA control cells (A–B). HSC-3 shRNA CTSK cells showed a reduction in cathepsin K mRNA levels when compared with wild type cells and HSC-3 cells transfected with a control shRNA (scramble) *p<0.0001 (C). The invasion depth, invasion area, and invasion index were all significantly reduced for HSC-3-shRNA CTSK cells (*p = 0.0006, **p<0.0001, and ***p = 0.0008, respectively) (D–F). Scale bars 200 µm.