Figure 3. IL-10-GFP+ B-cells reduce cerebral inflammatory responses post-MCAO.
Determinations of: A. total TNF-α production by CD45+ cells; B. TNF-α+CD3+ T-cells; and C. TNF-α+CD11b+ cells quantified in the nonischemic (left) and ischemic (right) hemispheres from µMT−/− mice transferred with medium or IL-10-GFP+ B-cells after 48 hours of MCAO. Values represent mean numbers (±SEM) of indicated cell subsets from 4–5 mice of each group, from at least 2 separate experiments. Statistical analysis was performed with ANOVA followed by Neuman-Kuels post hoc test. Significant differences between sample means are indicated (*p≤0.05).