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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: J Neurochem. 2013 Jun 10;126(4):462–472. doi: 10.1111/jnc.12309

Figure 2. Differential effects on subcellular distributions when Kv4.2 or Kv4.2(W8A,F11A) are co-expressed with KChIP3 or DPP6.

Figure 2

Projection images of confocal stacks. A) Im-munofluorescence studies on COS7 cells transfected with KChIP3 and Kv4.2(EGFP) or Kv4.2(W8A,F11A). Kv4.2(EGFP) and KChIP3 redistribute together onto the surface membrane compartment, whereas co-expressed Kv4.2(W8A,F11A) and KChIP3 remain in separate subcel-lular compartments: Kv4.2(W8A,F11A) –intracellular membranes, KChIP3- cytoplasm. B) Im-munofluorescence studies on COS7 cells transfected with myc-DPP6 and Kv4.2(EGFP) or Kv4.2(W8A,F11A). Following co-expression with DPP6, both Kv4.2(EGFP) and Kv4.2(W8A,F11A) redistribute onto the surface membrane compartment and extensively co-localize with DPP6. Scale bars are 20 μm.