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One pot radiosynthesis of [11C]PF-04457845. With 2.63 ± 0.58 GBq in the final bottle, the isolated radiochemical yield was 4.5 ± 1.3% based upon starting [11C]CO2 (uncorrected for decay) with a radiochemical purity of 98.4 ± 1.3%, and specific activity of 73.5 ± 8.2 GBq/μmol at the end of synthesis (25 ± 2 min; n = 4).
