Figure 3. Spontaneous locomotion in adolescent mice measured in the home-cage, expressed in counts per minute (mean ± SEM), during a single 2-hr session starting 30 minutes after i.p injection with either vehicle (VEH) or JWH-018 (0.3 mg/kg), during the first (P23) (panel a) and last (P33) (panel b) administration day.

*p < 0.05 and **p < 0.01 significantly different from EE-VEH. Data are expressed as average ± SEM. (AFR = animal facility rearing; EE = environmental enrichment; VEH = vehicle; JWH-018 = JWH-018).