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. 2013 May 21;41(14):7073–7083. doi: 10.1093/nar/gkt423

Figure 6.

Figure 6.

A major branch of the late-stage assembly of the bacterial 50S subunit in vivo. (A) Cartoon representation of the 45S intermediate in the state II, featuring a loosely attached 5S rRNA, a flexible CP domain (dash lines) and a ‘trapped’ conformation of H38 (yellow lines). (B) Cartoon representation of the 45S intermediate in the state I, where the rigidity of the CP is achieved and the interaction between the 5S rRNA and H38 is established. H38 is in a native-like conformation in state I. (C) Cartoon representation of the mature 50S structure. There are two major rate-limiting transitions in this assembly branch, the state II to I, and the state I to the mature conformation. Both transitions involve the structural remodeling of H38.