Table 1.
List of a core set of miRNAs involved in allergic inflammation, the direction of their change in expression, and their mRNA targets
| miRNA | Asthma | Eosinophilic Esophagitis |
Atopic Dermatitis |
mRNA Targets in Allergic Inflammation |
|---|---|---|---|---|
| Upregulated or downregulated in all three diseases |
||||
| let-7c | ↓ | ↓ | ↓ | IL-13 |
| miR-21 | ↑ | ↑ | ↑ | IL-12p35 |
| miR-142-5p | ↑ | ↑ | ↑ | |
| miR-142-3p | ↑ | ↑ | ↑ | |
| miR-146a | ↑ | ↑ | ↑ | STAT1 |
| miR-193b | ↓ | ↓ | ↓ | |
| miR-223 | ↑ | ↑ | ↑ | IGF1R |
|
|
||||
| Upregulated or downregulated in two diseases |
||||
| let-7a | ↓ | ND | ↓ | IL-13 |
| let-7b | ↓ | ND | ↓ | IL-13 |
| let-7d | ↓ | ND | ↓ | IL-13 |
| miR-146b | ↑ | ↑ | ND | |
| miR-155 | ↑ | ND | ↑ | CTLA4 |
| miR-365 | ND | ↓ | ↓ | |
| miR-375 | ND | ↓ | ↓ | |
ND, difference in expression not significantly different from control