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. Author manuscript; available in PMC: 2014 Jul 24.
Published in final edited form as: Neuron. 2013 Jul 3;79(2):322–334. doi: 10.1016/j.neuron.2013.05.012

Figure 5. Blockade of crossover inhibition and glutamate uptake synchronize EPSCs of ON and OFF RGCs.

Figure 5

(A) Representative simultaneous recording of EPSCs from ON and OFF RGCs in the presence of strychnine (500 nM), gabazine (5 µM) and TPMPA (50 µM). (B) Crosscorrelation (mean ± SEM, Control n = 15, -Gly -GABAA/Cn = 4) of excitatory synaptic conductances (g) of ON and OFF RGCs in control conditions (black) or in the presence of glycinergic- and GABAergic blockers (blue). (C) Representative EPSC traces from simultaneously recorded ON and OFF RGCs in the presence of the glutamate uptake inhibitor TBOA (25 µM). (D) Crosscorrelation (mean ± SEM, Control n = 15, -TBOA n = 5) of excitatory synaptic conductances in ON and OFF RGCs. As in (B) control results obtained in control conditions are depicted in black. Crosscorrelations recorded in the presence of TBOA are shown in orange. See also Figures S5 and S6.