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. Author manuscript; available in PMC: 2014 Jul 24.
Published in final edited form as: Neuron. 2013 Jul 3;79(2):322–334. doi: 10.1016/j.neuron.2013.05.012

Figure 7. Focal application of glutamate activates distinct currents in ON CBCs and antagonists of iGluRs and gap junctions blocks stage III waves in ON CBCs and RGCs.

Figure 7

(A) Schematic illustrating focal application of glutamate in the I PL. (B - D) Representative traces (top panels) and summary data (bottom panels) of currents elicited by glutamate in different BC types: Group I ON CBCs (B, n = 7), group II ON CBCs (C, n = 4) and RBCs (D, n = 5). (E, G) Dual current- (I = 0 pA, VRest ~ −65 mV) and voltage-clamp (EPSCs, VM ~ −60 mV) recordings from ON CBCs and ON RGCs, respectively. Traces are shown in control solution, during application of 90 µM AP5 and 20 µM NBQX (E) or 200 µM MFA (G), and after washout of these drugs. (F, H) Average (± SEM) rate of waves in these conditions (AP5, NBQX n = 5; MFA n = 6). See also Figures S7.