Figure 3.

Stress habituation and facilitation. Repeated exposure to the same stressor results in progressive diminution of response magnitude, thought to be mediated by structures such as the prefrontal cortex (PFC) and paraventricular thalamus (PVT). Exposure to a new stressor after either homotypic or hetertypic stressors causes a larger than normal (“sensitized' or “facilitated' response), which may be mediated by enhanced drive from the basolateral amygdala (BLA), PVT or locus coeruleus (LC).