Figure 5.

Comparison of robustness profiles of cell-cycle regulation between S. cerevisiae and S. pombe. The dotted blue line connects the functional orthologs within the ‘fragile core’ conserved in both yeasts (left). The dotted orange line connects the functional orthologs involved in the cytokinesis regulatory pathway of both yeasts (MEN and SIN). Some components involved in both MEN and SIN are omitted from the diagrams because their copy number limits were not measured. Data for S. cerevisiae are obtained from a previous study (Moriya et al, 2006). The original data are shown in Supplementary Table S8.