FIGURE 4. The monoubiquitination-mimicking p53 fusion protein can form tetramers in an oligomerization assay.
A equal amounts of total protein were incubated with 0, 0.01 %, and 0.1% gluteraldehyde on ice for 30 min and resolved on a 7% SDS-PAGEgel followed by Western blot using anti-p53 (DO-1) antibody. B, the in vitro oligomerization assay was repeated using purified GST-p53-UB protein incubated with increasing amounts of gluteraldehyde and resolved on a 7% SDS-PAGE followed by Western blot using DO-1.