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. Author manuscript; available in PMC: 2013 Aug 8.
Published in final edited form as: Mol Cell. 2006 Feb 3;21(3):307–315. doi: 10.1016/j.molcel.2006.01.020

Figure 2. A Model for the Role of Mdm2 in Cell Survival.

Figure 2

In unstressed cells, low levels of Mdm2 only induce monoubiquitination of p53, which is not sufficient for degradation, whereas ARF-BP1 may be the major E3 ligase responsible for p53 ubiquitination and degradation. Upon DNA damage, p53 becomes stabilized and activated by posttranslational modifications and other signaling pathways, which lead to induction of hdm2, COP1, and pirh2 genes (see text for details).