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Plasma nicotine levels after IV nicotine administration on two SPECT scan days for each subject: 1. before immunization (closed circles) and 2. after immunization (open circles) for each subject. Notably, average maximum concentration across subjects (Cmax; 9.1 vs 22.3ng/mL) and area under the curve (AUC; 1853 vs 2537 ng. min/ml) were significantly higher after immunization.
