Table 4.

Risk of Incident Dementia, Alzheimer Disease (AD), and Non-AD Dementia Associated With the Individual Frailty Components^*

Frailty Components	Dementia, HR (95% CI)	Possible or Probable AD, HR (95% CI)	Non-AD Dementia, HR (95% CI)
Weakness (grip strength)	1.06 (0.87–1.29)	1.04 (0.84–1.28)	1.28 (0.77–2.11)
Slowness (walking speed)	1.27 (0.96–1.69)	1.16 (0.85–1.59)	2.13 (1.09–4.16)
Low physical activity	0.97 (0.80–1.17)	0.95 (0.77–1.17)	1.03 (0.62–1.69)
Weight loss	0.88 (0.62–1.24)	0.92 (0.63–1.33)	0.72 (0.28–1.84)
Exhaustion	1.08 (0.82–1.40)	0.96 (0.72–1.30)	1.77 (0.95–3.31)

Notes: CI = confidence interval; HR = hazard ratio.

*From Cox proportional hazards regression model with age as the time scale, adjusted for age at baseline, sex, education, race, body mass index, depressive symptoms, antidepressant use, self-reported health, hypertension, diabetes, myocardial infarction, congestive heart failure, and smoking status and baseline Cognitive Abilities Screening Instrument (CASI) score.