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A significant effect of the interaction between presence of tonsillar hypertrophy (tonsillar size > 2+) and severity of OSA on morning serum cortisol levels was demonstrated (P = 0.04). Among children with hypertrophic tonsils, those with moderate-to-severe OSA had lower cortisol levels than subjects with mild OSA (P = 0.01) or controls (P = 0.04). No significant differences were identified in subjects without tonsillar hypertrophy.
