Table 2. Comparison of characteristics of BRCA-positive patients in clinical stream and population-based stream.
Clinical referral genetic testing (n=22) | Jewish population genetic testing (n=68) | Univariate P | |
---|---|---|---|
Mean age (years) |
46.1 (28–71) |
44.2 (24–68) |
0.51 |
Personal history of cancer | |||
Any | 9 (23.6%) | 0 (0.0%) | <0.0001 |
Ovary | |||
Breast | |||
None |
|
|
|
Ethnic group | |||
Jewish | 3 | 68 | <0.0001 |
Other white | 18 | 0 | |
Asian | 0 | 0 | |
Black | 1 | 0 | |
Other |
0 |
0 |
|
First-degree relative with ovarian cancer |
6 of 22 (27.2%) |
3 of 68 (4.4%) |
0.006 |
First-degree relative with breast cancer |
13 of 22(59.1%) |
8 of 68 (11.8%) |
<0.0001 |
Proband met Ontario genetic testing criteria |
22 of 22 (100%) |
26 of 68 (38.2%) |
<0.0001 |
Mutation (proband) | |||
BRCA1 | 10 (45.5%) | 25 (36.8%) | 0.62 |
BRCA2 | 12 (54.6%) | 43 (63.2%) |