Table 2. Factors associated with poor overall survival or poor recurrence-free survival among all HBV–HCC patients.
|
Overall survival |
Recurrence-free survival |
|||||
|---|---|---|---|---|---|---|
| |
Univariate |
Multivariate |
Univariate |
Multivariate |
||
| P-value | HR (95% CI) | P-value | P-value | HR (95% CI) | P-value | |
| Gender (male) |
0.02 |
|
|
0.04 |
|
|
| Age (>56) |
0.83 |
|
|
0.74 |
|
|
| Race (Asian) |
0.003 |
|
|
0.07 |
|
|
| Poorly differentiated tumour |
<0.001 |
|
|
0.001 |
1.58 (1.01–2.47) |
0.04 |
| Microvascular invasion |
0.03 |
|
|
0.05 |
|
|
| Macrovascular invasion |
<0.001 |
|
|
<0.001 |
6.17 (2.06–18.51) |
0.001 |
| Tumour number >1 |
0.40 |
|
|
0.68 |
|
|
| Tumour size (cm) |
<0.001 |
1.17 (1.09–1.26) |
<0.001 |
<0.001 |
1.08 (1.04–1.13) |
<0.001 |
| Resection margin (cm) |
0.04 |
1.34 (1.00–1.79) |
0.05 |
0.33 |
|
|
| Anatomic resection |
<0.001 |
|
|
0.002 |
|
|
| Detectable circulating HBV DNA |
0.39 |
|
|
0.87 |
|
|
| ALT (>30 units l−1) |
0.001 |
|
|
0.02 |
|
|
| AFP (>20 ng ml−1) |
0.002 |
2.62 (1.16–5.95) |
0.02 |
0.01 |
|
|
| HAI grade |
0.22 |
|
|
0.001 |
1.22 (1.09–1.36) |
<0.001 |
| Ishak stage 6 | 0.008 | 4.86 (2.29–10.28) | <0.001 | 0.05 | 1.88 (1.19–2.99) | 0.007 |
Abbreviations: CI=confidence interval; HAI=histologic activity index; HBV=hepatitis B virus; HCC=hepatocellular carcinoma; HR=hazard ratio.